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Wolfson Brain Imaging Centre

Department of Clinical Neurosciences

Studying at Cambridge

Graduate Research Projects


One of the primary objectives of the Department of Clinical Neurosciences is the provision of co-ordinated training for both medically qualified and non-medical graduates. Because the causes and treatment of brain dysfunction and damage are so varied, and the processes that determine whether or not the brain will recover from damage are equally diverse, the research training offered is strongly cross-disciplinary.  The strength of the Department is that it can offer training across the range of clinically-related neuroscience, with expertise drawn from its four constituents: Cambridge Centre for Brain Repair, Neurology Unit, Neurosurgery Unit and the Wolfson Brain Imaging Centre.  Many graduate research projects span two or more of these units.

The Wolfson Brain Imaging Centre conducts research in the development and application of advanced imaging techniques using Positron Emission Tomography (GE Advance, GE cyclotron, CTI-Concorde microPET), Magnetic Resonance Imaging (Siemens 3T wholebody MRI), and Magnetic Resonance Spectroscopy. Active research programmes exist with opportunities for chemists, pharmacologists, biologists, physicists, computer scientists and clinicians. Examples include the development of novel radiopharmaceuticals, reconstruction algorithms, scanner modelling and kinetic modelling (PET), diffusion tensor analysis and modelling, sequence development (MRI), image possessing, fMRI. These techniques are used to study the development and treatment of a wide range of diseases including stroke, traumatic brain injury, dementia, diabetes, athersclerosis, and cancer.

We have over 60 PhD students with backgrounds in medical, biological and physical sciences, as well as an EU funded training programme in association with 10 other Universities.  Full information about PhD entry for 2013 will be found here.  Applications are now open.

Application of solid phase chemistry to the synthesis of PET tracers

Development of Cu64 labelled PET tracers

Development of markers of protein aggregates.

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Recent publication in collaboration with the CIDDRG.

Jan 09, 2014

Defective mitochondrial function in vivo in skeletal muscle in adults with Down’s syndrome.

Dr. Acosta-Cabronero - Paper recently published in PLOS ONE

Dec 05, 2013

In Vivo Quantitative Susceptibility Mapping (QSM) in Alzheimer's Disease

Imaging study shows dopamine dysfunction is not the main cause of Attention Deficit Hyperactivity Disorder (ADHD)

Oct 29, 2013

Research suggests that the main cause of ADHD may lie instead in structural differences in the grey matter in the brain.

NIMROD study "The drive for dementia diagnosis"

Oct 11, 2013

An important new study at CPFT led by Consultant Psychiatrist Prof John O’Brien and Consultant Neurologist Dr James Rowe is looking into the possible role of the immune system in dementia and related memory disorders.

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