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Wolfson Brain Imaging Centre

Department of Clinical Neurosciences

Studying at Cambridge

 

Latest News

Recent publication in collaboration with the CRIC, Edinburgh

Real-time 4D phase unwrapping applied to magnetic resonance elastography

Following a long collaboration with the Clinical Research Imaging Centre in Edinburgh on Magnetic Resonance Elastography (MRE), Dr Marius Mada contributed to the publishing of a new algorithm for real-time 4D phase unwrapping.

 

The article is available online at http://onlinelibrary.wiley.com/doi/10.1002/mrm.25332/abstract

BBC Cambridgeshire Big Breakfast - Featuring WBIC's 3D printing services

BBC Cambridgeshire Big Breakfast - Featuring WBIC's 3D printing services - Follow the Link to the PodCast

 

WBIC has been offering 3D printing services to the NHS for nearly two years now. In a collaboration with the Maxillofacial Laboratory, Dr Marius Mada transformed CT images of patients suffering from traumatic brain injuries or facial bone tumours into plastic replicas using Computer Aided Design software and a commercial 3D printer. The models are helping the surgeons in the theatre or the technicians when they construct the cranioplasty plates.

We intend to extend this collaboration further and have more patients benefitting from this technology.

Our collaboration got the attention of the media and Dr Marius Mada and Mr Malcom Cameron from Addenbrooke's had a live intervention on BBC Radio Cambridgeshire on the 12th of June.

http://www.bbc.co.uk/programmes/p0201k5m 

(starts at 1:20:00 mins in)

Wolfson Brain Imaging Centre/CBSU 7T Study Day

Dr. Adrian Carpenter, Dr. Guy Williams and Dr. Marta Correia put together an interesting event for the Neuroscience community in Cambridge on the 30th of January at 2pm.

This study afternoon brings together four international leaders in 7T human imaging, who will share their experience of installing and using 7T human scanner.  The afternoon ends with an update from the Siemens Ultra High Field group.  The meeting will be of interest to researchers interested in what 7T imaging can offer.

Please book your place in advance to avoid dissapointment.

Recent publication in collaboration with the CIDDRG.

Defective mitochondrial function in vivo in skeletal muscle in adults with Down’s syndrome.

A novel and patient friendly method for measuring PCr kinetics post exercise has been designed and developed here at the WBIC by Dr Alison Sleigh, which has enabled the study of mitochondrial function in vivo in cohorts of people with reduced intellectual ability.

We have collaborated with researchers at the Cambridge Intellectual and Developmental Disabilities Research Group (CIDDRG) to publish the first study to investigate mitochondrial function in vivo in people with Down’s syndrome (DS) using 31P-MRS.  Our finding of defective mitochondrial function in skeletal muscle of adults with DS, compared with physical activity matched controls with an intellectual disability without DS, is consistent with previous in vitro studies and supports a theory of a global mitochondrial defect in DS.

Publication at PLOS ONE.

Dr. Acosta-Cabronero - Paper recently published in PLOS ONE

In Vivo Quantitative Susceptibility Mapping (QSM) in Alzheimer's Disease

Over the last 2 years Dr Julio Acosta-Cabronero together with WBIC collaborators have been optimising the Magnetic Susceptibility MRI sequence and developing post processing methods.

This study presents a details methodological QSM framework for semi-automated magnetic susceptibility measurements and offers a proof of concept of its strong potential to yield new insights in neurodegenerative diseases such as Alzheimer’s disease.”

Follow the link: http://dx.plos.org/10.1371/journal.pone.0081093

Imaging study shows dopamine dysfunction is not the main cause of Attention Deficit Hyperactivity Disorder (ADHD)

Research suggests that the main cause of ADHD may lie instead in structural differences in the grey matter in the brain.

"These findings question the previously accepted view that major abnormalities in dopamine function are the main cause of ADHD in adult patients." Professor Trevor Robbins

Follow the link to read more:

NIMROD study "The drive for dementia diagnosis"

An important new study at CPFT led by Consultant Psychiatrist Prof John O’Brien and Consultant Neurologist Dr James Rowe is looking into the possible role of the immune system in dementia and related memory disorders.


An important new study at CPFT led by Consultant Psychiatrist Prof John O’Brien and Consultant Neurologist Dr James Rowe is looking into the possible role of the immune system in dementia and related memory disorders. The NIMROD (Neuroimaging of Inflammation in Memory and Other Disorders) study, in close collaboration with the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, aims to understand the role of inflammation in several forms of dementia, memory loss and depression. It also aims to identify the changes in the immune system, in the brain and rest of the body.

http://www.cpft.nhs.uk/about-us/drive-for-dementia-diagnosis.htm

BBC News - Brain scan study to understand workings of teenage mind

Featuring MRI imaging at the Wolfson Brain Imaging Centre - Researchers in Cambridge have begun a study to understand the teenage brain. Follow the link to the BBC News Website: http://m.bbc.co.uk/news/health-22510866

Compute/Cluster Server Consolidation.

Work has completed to consolidate our current compute and cluster servers at the WBIC. By utilising the latest server technology we have reduced our current compute/cluster server count from 76 Servers to just 8, but this will constitute an increase of approx 50% more CPU/Memory processing power available, as well as reducing our energy footprint by 80%.

Work has completed to consolidate our current compute and cluster servers at the WBIC. By utilising the latest server technology we will be able to reduce our current compute/cluster server count from 76 Servers to just 8, but in turn this will constitute an increase of approx 50% more CPU/Memory processing power available than was previously, together with simplifying the current setup that has historically grown over time at the WBIC.

Compute servers:- The following servers are to be withdrawn from service(cs5,cs6,cs7,psych0,psych1,psych2,psych3,psych4,psych5,psych6,psych7,abi0,abi1,neurol2,neurol3,neurol4), and will be replaced with 4 new servers, cs1,cs2,cs3 and cs4 with each server benefitting from 16 CPU's and 32GB RAM.

Cluster Servers:- All the current cluster servers are to be withdrawn from service (cluster0-x,cluster1-x,cluster2-x,cluster3-x), and will be replaced with 4 new servers, cluster0-0, cluster1-0,cluster2-0 and cluster3-0 with each of these servers benefitting from 32 CPU's and 64GB RAM.

Panorama:The Mind Reader - Unlocking My Voice

Featuring MRI imaging at the Wolfson Brain Imaging Centre - scheduled for broadcast on BBC ONE-Tuesday November 13th at 10:35pm Author - Vicky Lupson

In a world exclusive, Panorama follows a group of severley brain injured patients and reveals the revolutionary efforts made to help them communicate with their families and the outside world.

Never before filmed, this Panorama Special spent more than a year with a group of vegetative patients in Britain and Canada.

They witness the moment when a patient regarded as vegative for more than a decade is able to answer a series of questions whilst inside a brain scanner.

The findings have profound implications for the patients and their families, as well as ethical consequences for scientists and medical staff.

 

New high resolution NMR instrument installed in the Molecular Imaging Chemistry Laboratory (MICL)!

Author - Dr R E Canales Candela

The new Bruker instrument is a high performance digital AVANCE-III 300 MHz two channel (broadband H+X) NMR spectrometer. The NMR facility is capable of running all modern NMR experiments and on all standard NMR accessible nuclei including proton, carbon, fluorine, phosphorus, nitrogen, boron, etc. The AVANCE III NANOBAY console has a fully flexible research-level design suitable for use with multiple probeheads and accessories, routine and non standard or custom experiments (contact Dr R Canales erc28@wbic.cam.ac.uk)

 

Notes: A link to an additional page with further information is under construction.

Upgrade to Simultaneous PET/MR Scanner

Author - Dr R Hawkes

The Isaac Newton Trust and the Clinical School are jointly providing funding of £48,012 to  upgrade/refurbishment our novel simultaneous PET/MR scanner. This instrument was a joint development between the Wolfson Brian Imaging Centre and the Cavendish laboratory and was initially funded by the EPSRC. Simultaneous measurement is a new approach to combine functional and morphological imaging in one instrument. The value of PET lies in its high-sensitivity to measuring biomarkers, but it does not provide consistent morphology. MR has lower sensitivity, but produces high soft-tissue contrast and our initial experiments have demonstrated some of the potential of simultaneous measure. The upgrade will provide functional MR (fMRI) and should result in the instrument being available for routine use.

3D Printing Capabilities at WBIC

Dr Marius Mada has been successful in his application to the Marmaduke Sheild Fund to purchase an HP 3D Printer. This will be used to rapid prototype custom parts for both MRE (Magnetic Resonance Elastography) and preclinical imaging studies at the Laboratory for Molecular Imaging.  For further information if you would like to try out the printer contact Dr Mada by email.

Powerful new means of accessing PET radiotracers for brain imaging

A novel methodology for rapid and direct synthesis of PET probes has  been developed in partnership with researchers from the National  Institute of Mental Health.

The publication is here.

Abnormal Brain Structure Implicated in Stimulant Drug Addiction

Abnormalities in the brain may make some people more likely to become drug addicts is the conclusion of a major study conducted at the Wolfson Brain Imaging Centre.

Lead by Karen Ersche,  and recently published in Science, the study combined diffusion and structural imaging to differences in the brains of addicts and their non-addicted brothers and sisters.

The study is attracting media interest as well as comment from leaders in the field.

MHRA-PET Expert Panel

MHRA-PET Expert Panel - An expert panel on regulatory affairs to help researchers deal with the UK regulatory framework for medicines, specifically as applied to Positron Emission Tomography (PET) research.

WBIC Website

We have recently moved the  WBIC website to run on the University's Falcon CMS service.  If you find broken links or pages that are missing,  please contact webmaster@wbic.cam.ac.uk with any feedback.

RSS Feed Latest news

Recent publication in collaboration with the CRIC, Edinburgh

Jun 23, 2014

Real-time 4D phase unwrapping applied to magnetic resonance elastography

BBC Cambridgeshire Big Breakfast - Featuring WBIC's 3D printing services

Jun 12, 2014

BBC Cambridgeshire Big Breakfast - Featuring WBIC's 3D printing services - Follow the Link to the PodCast

Recent publication in collaboration with the CIDDRG.

Jan 09, 2014

Defective mitochondrial function in vivo in skeletal muscle in adults with Down’s syndrome.

Dr. Acosta-Cabronero - Paper recently published in PLOS ONE

Dec 05, 2013

In Vivo Quantitative Susceptibility Mapping (QSM) in Alzheimer's Disease

View all news