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Facilities

The laboratory consists of four integrated areas covering the key stages required for the development and preparations of molecular imaging probes: i) an organic chemistry area for the generation of novel chemical entities and precursors, ii) an analytical area for chemical and radiochemical identification, iii) a radiochemistry area for synthesis and purification of radiotracers and iv) a radiopharmacology area for the biological characterisation and validation of imaging probes.

 

Synthetic Chemistry Laboratory

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Our synthetic chemistry has eight 1.5 fumehoods, allowing every member of the MICL to have their own research space. The lab is also equipped with an API Mass Spectrometer a Gilson automated column system and a 300 MHz NMR machine fitted with a multi-nuclear probe allowing analysis of compounds by 1H, 13C and 19F NMR.

 

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Radiochemistry Laboratory

 

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Radiochemistry is fundamental to the MICL, our radiochemical facilities include 3 hot cells equipped with a Tracerlab FxFn, an Advion Minute Man micro fluidic system, and a GE FASTlab, we also have a fourth hot cell for manual radiochemical reactions. For reaction analysis we have 3 HPLC machines.

 

Radio Pharmacology Laboratory

Many projects in the MICL involve analysis of radiotracers in-vitro and in-vivo. The radio-pharmacology laboratory allows us to conduct simple binding assays, autoradiogrphy and metabolite analysis on-site. We also have access to the WBIC microPET which allows us to do our own pre-clinical imaging. 

 

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