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Wolfson Brain Imaging Centre

Department of Clinical Neurosciences

Studying at Cambridge


Alison Sleigh


Senior Research Associate

Wolfson Brain Imaging Centre

+44(0)1223 746460


I pursued my passion for applied physics and completed my PhD in fMRI at the Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham. Since 2003 I have specialised in the field of MR in metabolic research at the WBIC, in particular using 1H, 31P and 13C spectroscopy. 


Selected publications

A. Sleigh, D.B. Savage, G.B. Williams, D. Porter, T.A. Carpenter, K.M. Brindle, G.J. Kemp, "31P magnetization transfer measurements of Pi->ATP flux in exercising human muscle", J Appl Physiol (2016) jap.00871.2015

A.Sleigh, V. Lupson, A. Thankamony, D.B. Dunger, D.B. Savage, T.A. Carpenter, G.J. Kemp, "Simple and effective exercise design for assessing in vivo mitochondrial function in clinical applications using 31P magnetic resonance spectroscopy", Sci Rep (2016) 6:19057

A.C. Phillips, A. Sleigh, C.J. McAllister, S. Brage, T.A. Carpenter, G.J. Kemp, A.J. Holland, "Defective Mitochondrial Function In Vivo in Skeletal Muscle in Adults with Down's Syndrome: A 31P-MRS Study", PLoS One (2013) 8(12): e84031.

A. Sleigh, A. Stears, K. Thackray, L. Watson, A. Gambineri, S. Nag, V.I. Campi, N. Schoenmakers, S. Brage, T.A. Carpenter, P.R. Murgatroyd, S. O’Rahilly, G.J. Kemp, D.B. Savage, “Mitochondrial oxidative phosphorylation is impaired in patients with congenital lipodystrophy”, JCEM (2012) 97(3): E438.

A. Sleigh, P. Raymond-Barker, K. Thackray, D. Porter, M. Hatunic, A. Vottero, C. Burren, C. Mitchell, M. McIntyre, S. Brage, T.A. Carpenter, P.R. Murgatroyd, K.M. Brindle, G.J. Kemp, S.O’Rahilly, R.K. Semple, D.B. Savage, “Mitochondrial dysfunction in patients with primary congenital insulin resistance”, J Clin Invest (2011) 121(6): 2457.


Internal collaborators at         

Wellcome Trust/MRC Institute of Metabolic Science, Cambridge

NIHR/Wellcome Trust Clinical Research Facility, Cambridge

Cambridge Intellectual and Developmental Disabilities Research Group, Cambridge


External collaborators

Professor Graham Kemp, University of Liverpool, Liverpool, UK


For more information on my research interests please click here